Kissing complex-based aptaswitches. Jean-Jacques Toulmé1,2, Eric Dausse1, Guillaume Durand1,3, Corinne Ravelet4, Eric Peyrin4, Laurent Azéma1. 1, ARNA Laboratory, Inserm U1212, CNRS UMR5320, University of Bordeaux, Bordeaux, France 2, Novaptech, Pessac, France 3, Present address : Department of Nutrition, Health, and Agricultural Sector, Bordeaux Sciences Agro, Gradignan, France 4, Department of...
Aptamer carriers for Cancer Stem Cell-Targeted Delivery of Therapeutic miRNAs Carla Lucia Esposito, Silvia Nuzzo, Anna Rienzo, Silvia Catuogno and Vittorio de Franciscis Institute of Experimental Endocrinology and Oncology – CNR, Naples, Italy defranci@unina.it Glioblastoma (GBM) is the most common primary brain tumor and one of the most...
Therapeutic and Diagnostic Applications of Rapidly Reversible Aptamers Bruce Sullenger, Ruwan Gunaratne, James Frederiksen, Kady-Ann Steen-Burrell, Bethany Gray Duke Translational Research Institute, Department of Surgery, Duke University, Durham, North Carolina, USA bruce.sullenger@duke.edu Clinical evaluation of our factor IXa aptamer in two thousand patients undergoing angioplasty has demonstrated that aptamers...
Cell-targeted RNA therapies for Hyperproliferative Cardiovascular Disease William H Thiel1, Carla L Esposito2, David D Dickey1, Justin P Dassie1, Matthew E Long3, Joshua Adam1, Jennifer Streeter1, Brandon Schickling1, Maysam Takapoo1, Katie S Flenker1, Julia Klesney-Tait1, Vittorio de Franciscis2, Francis J Miller Jr1,4, Paloma H Giangrande1 1 Department...
Improvement of aptamers using PATTERNITY-seq (high-throughput analysis of sequence patterns and paternity relationship between them). Nam Nguyen Quang1,2,3, Clément Bouvier1,2,3, Benoit Lelandais1,2,3 and Frédéric Ducongé1,2,3. 1, The Neurodegenerative Diseases Laboratory (LMN), CEA-CNRS UMR 9199, Université Paris-Saclay, Fontenay aux roses, France 2, Molecular Imaging Research Center (MIRCen), Institute of...
Engineered riboswitches – an alternative means to control gene expression. Marc Vogel, Florian Groher, Martin Rudolph, Julia Weigand, Beatrix Suess Synthetic Biology and Genetics, Department of Biology, Technical University Darmstadt, Schnittspahnstr. 10, 64287 Darmstadt, Germany bsuess@bio.tu-darmstadt.de Numerous synthetic RNA-based control devices, so called engineered riboswitches, have been developed in...
Fluorescence Anisotropy Spectroscopy in Aptamer-based Biosensing Eric Peyrin, Emmanuelle Fiore, Valérie Guieu, Sandrine Perrier, Corinne Ravelet Département de Pharmacochimie Moléculaire, Université Grenoble Alpes, UMR 5063 CNRS, ICMG FR 2607, Campus universitaire, Saint-Martin d’Hères, France Eric.peyrin@ujf-grenoble.fr The fluorescence anisotropy/polarization (FA/FP) spectroscopy is very popular in the biochemical/biophysical field for the...
Adaptive Dynamic Artificial Poly-ligand Targeting (ADAPT): a highly multiplexed aptamer-based biomarker discovery platform Günter Mayer1,2, Valeriy Domenyuk1, Zhenyu Zhong1, Adam Stark1, Jie Wang1, Sonal Tonapi, Heather O’Neill1, Nianqing Xiao1, Mark R. Miglarese1, Michael Famulok1,2,3, and David B. Spetzler1 1Caris Life Sciences, Phoenix, AZ; 2LIMES Program Unit Chemical Biology...
Bio Dr. H. Tom Soh is a Professor at Stanford University with a joint appointment in the department of Electrical Engineering (School of Engineering) and Radiology (School of Medicine). He received his B.S. with a double major in Mechanical Engineering and Materials Science with Distinction from...
Bio Dr. Samie Jaffrey is a Professor of Pharmacology at the Weill Medical College of Cornell University. He received an M.D. and Ph.D. from Johns Hopkins School of Medicine where he also conducted postdoctoral work. Dr. Jaffrey’s laboratory focuses on identifying novel RNA regulatory pathways the...