Friday August 3

Morning Session: Modern Aptamers and Structures

8:00 — Registration and breakfast


8:30 – 8:45 — Opening Remarks

Larry Gold

8:45 – 9:30 –Expanding Aptamer Chemistries and Applications

Andrew Ellington, Fraser Professor of Biochemistry, University of Texas at Austin

9:30 – 10:15 – From Phage Biology to Human Health: a Purposeful Walk Through Randomness

Nebojsa Janjic

10:15 – 10:45 – Heterochiral Nucleic Acid Technologies

Jonathan Sczepanski, Assistant Professor, Texas A&M University

 10:45 – 11:15Break

11:15 – 11:40 – From Aptamer Structure to Application: Combination of Factor Xa aptamer and small molecule active site inhibitor are potent and reversible anticoagulants for cardiopulmonary bypass surgery,

Bruce Sullenger, Professor of Surgery, Associate Professor in Molecular Genetics and Microbiology, Professor of Pharmacology and Cancer Biology, Duke University

11:40 – 12:00 – Therapeutic Aptamers Based on 2-Fully Modified RNAs and Novel Selection Strategies

Rihe Liu, Associate Professor, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill

12:00 – 12:45 – A Short History of RNA Structure

Tom Cech, Distinguished Professor, University of Colorado Boulder; Director, BioFrontiers Institute

12:45 – 2:00Lunch

Afternoon Session: Better Statistics and Chemistry

2:00 – 2:30 — Creating Efficiencies and Establishing Reproducible Research in Insight Discovery

Kirk DeLisle, Director of Bioinformatics, SomaLogic

2:30 – 3:00 — AptaSUITE – A Bioinformatics Framework for the Comprehensive Analysis of HT-SELEX Experiments

Jan Hoinka, National Center of Biotehcnology Information, National Library of Medicine, NIH

3:00 – 3:30 — Graphical Analysis of High-Throughput Sequencing Data to Study the Molecular Evolution of Aptamers

Frédéric Ducongé, Scientist, CEA, DRF, Institute François Jacob, MIRCen

3:30 – 4:00Break

4:00 – 4:30 — Engineering Functional Xeno Nucleic Acids Using Synthetic Genetics

Alex Taylor, Investigator Scientist, MRC laboratory of Molecular Biology

4:30 – 4:50 — Tunable Cytotoxic Agents for the Treatment of Prostate Cancer

Bethany Powell Gray, Duke University Medical Center

4:50 – 5:15 — Highly Efficient Expression of Circular RNA: A Novel Platform for RNA Synthetic Biology

Jacob Litke, Weill Cornell Medicine, PhD Candidate

5:15 – 6:00 — RNA Aptamers as Genetic Control Devices – the Potential of Riboswitches as Synthetic Elements for Regulating Gene Expression

Beatrix Suess, Professor, Chemical and Synthetic Biology, Technical University Darmstadt, Germany

6:00 — Poster Session

8:00 pm

Gala Dinner – Boulder Museum of Contemporary Art

Saturday August 4th

Morning Session: Nucleic Acid Movements and Functions

8:00  – Breakfast

8:30 – 8:45 – Opening Remarks

Jean-Jacques Toulmé

8:45 – 9:30 – Are Aptamers in Dicer’s Future?

Brenda Bass, Distinguished Professor, H.A and Edna Benning Presidential Endowed Chair, Dept. of Biochemistry, University of Utah

9:30 – 10:00 – A Multi-Color Riboswitch-Based Platform for Live Cell Imaging of RNA in Mammalian Cells

Esther Braselmann, University of Colorado Boulder, Department of Biochemistry and BioFrotiers Institute

10:00 – 10:30 – A Light Dependent Aptamer-Photoreceptor System for the Control of RNA Function in Cells

Günter Mayer, University of Bonn

10:30 – 11:00Break

11:00 – 11:30 – RNA Inhibitors of Nuclear Proteins Responsible for Multiple Organ Dysfunction Syndrome

Paloma Giangrande, Associate Professor of Internal Medicine – Hematology, Oncology and Blood and Marrow Transplantation
Associate Professor of Radiation Oncology, University of Iowa

11:30 – 12:00 – Aptamer-STAT3-RNA bio-drugs as novel tool to eradicate glioblastoma stem-like cells

Vittorio De Franciscis, CNR-IEOS

12:00 – 1:15Lunch

Afternoon Session: Wonderful Chemistry and Applications

1:15 – 2:00 – Intracellular Aptamers

Donald Burke, Professor & Interim Chair, Dept. of Molecular Microbiology & Immunology, University of Missouri

2:00 – 2:30 – Enzyme modified DNA-surfactants: from nanoscale assembly to gene regulation

Jessica Rouge, Assistant Professor, University of Connecticut

2:30 – 3:00 – Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging

Ralf Jungmann, Professor, Max Planck Institute of Biochemistry

3:00 – 3:20 – Single-particle tracking of receptor tyrosine kinases in living cells using DNA-based aptamers

Mike Hellemann, Professor, Goethe-University Frankfurt

3:20 – 3:50Break

3:50 – 4:20 – Signal-tunable aptamer probe to guide precision tumor debulking

Youli Zu, Professor and Director of Hematorpathology, Houston Methodist Hospital

4:20 – 4:50 – RNA aptamers targeting transmembrane receptor tyrosine kinases (RTKs) act like RNAi in glioblastoma

Sorah Yoon, Staff Scientist, Beckman Research Institute of City of Hope

4:50 – 5:20 – C10.36 recognizes a surface spliceosomal complex andinduces aberrant splicing in B-cell lymphoma cells

Vaishali Pannu, Research Scientist I, Caris Life Sciences, Inc.

5:20 – 6:00 – Selection of RNaseA-mimicking DNAzymes with amines, imidazoles, and guanidines that cleave RNA: lessons for aptamer selections

David Perrin, Professor, Dept. of Chemistry, The University of British Columbia, Canada

6:00 – 6:15 pm