[vc_row row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” header_style=”” parallax_content_width=”in_grid” anchor=”” in_content_menu=”” content_menu_title=”” content_menu_icon=”” angled_section=”no” angled_section_position=”both” angled_section_direction=”from_left_to_right” text_align=”left” video=”” video_overlay=”” video_overlay_image=”” video_webm=”” video_mp4=”” video_ogv=”” video_image=”” background_image=”” background_image_as_pattern=”without_pattern” section_height=”” parallax_speed=”” background_color=”” border_color=”” row_negative_margin=”” side_padding=”” parallax_side_padding=”” padding_top=”” padding_bottom=”” color=”” hover_color=”” more_button_label=”” less_button_label=”” button_position=”” css_animation=”” transition_delay=””][vc_column width=”1/1″][vc_empty_space height=”32px” image_repeat=”no-repeat”][vc_column_text]
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O2 – Sondes Guedich1, Mireille Baltzinger1, Stéphane Thore2, Eric Ennifa1, Philippe Dumas1, Dominique Burnouf1
Folding Dynamics of TPP Riboswitches.
1, IBMC-CNRS, Université de Strasbourg, France; 2, Université de Bordeaux, Inserm, CNRS, Bordeaux, F33000 France.
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O3 – David P. Horning1 and Gerald F. Joyce1
Amplification of RNA by an RNA Polymerase Ribozyme
The Scripps Research Institute, La Jolla, CA, USA
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O4 – Pascale Cossart
Riboswitches : lessons from Listeria
Pasteur Institute, Paris, France
[/vc_column_text][/vc_column][/vc_row][vc_row row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” header_style=”” parallax_content_width=”in_grid” anchor=”” in_content_menu=”” content_menu_title=”” content_menu_icon=”” angled_section=”no” angled_section_position=”both” angled_section_direction=”from_left_to_right” text_align=”left” video=”” video_overlay=”” video_overlay_image=”” video_webm=”” video_mp4=”” video_ogv=”” video_image=”” background_image=”” background_image_as_pattern=”without_pattern” section_height=”” parallax_speed=”” background_color=”” border_color=”” row_negative_margin=”” side_padding=”” parallax_side_padding=”” padding_top=”” padding_bottom=”” color=”” hover_color=”” more_button_label=”” less_button_label=”” button_position=”” css_animation=”” transition_delay=”” el_id=””][vc_column width=”1/1″][vc_empty_space height=”25px” background_image=”” image_repeat=”no-repeat”][vc_separator type=”normal” position=”center” color=”#303030″ transparency=”” thickness=”1″ width=”” width_in_percentages=”” up=”” down=””][vc_empty_space height=”25px” background_image=”” image_repeat=”no-repeat”][/vc_column][/vc_row][vc_row row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” header_style=”” parallax_content_width=”in_grid” anchor=”” in_content_menu=”” content_menu_title=”” content_menu_icon=”” angled_section=”no” angled_section_position=”both” angled_section_direction=”from_left_to_right” text_align=”left” video=”” video_overlay=”” video_overlay_image=”” video_webm=”” video_mp4=”” video_ogv=”” video_image=”” background_image=”” background_image_as_pattern=”without_pattern” section_height=”” parallax_speed=”” background_color=”” border_color=”” row_negative_margin=”” side_padding=”” parallax_side_padding=”” padding_top=”” padding_bottom=”” color=”” hover_color=”” more_button_label=”” less_button_label=”” button_position=”” css_animation=”” transition_delay=”” el_id=””][vc_column width=”1/4″][vc_column_text]10:50 – 12:10[/vc_column_text][/vc_column][vc_column width=”3/4″][vc_column_text css=”.vc_custom_1465210819817{margin-bottom: 10px !important;}”]
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O6 – D.D. Vo1, T.P.A. Tran1, A. Di Giorgio1, F. Darfeuille2, Cathy Staedel2, Maria Duca1
Oncogenic microRNAs biogenesis as a drug target: new applications for synthetic RNA ligands
1 Institut de Chimie de Nice (ICN) UMR7272
2 Laboratoire ARNA, U1212, INSERM – Université de Bordeaux
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O7 – Saki Matsumoto, Asako Murata, Kazuhiko Nakatani
Regulation of gene expression by ligand-inducible –1 ribosomal frameshifting
Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research (ISIR), Osaka University, Ibaraki, Osaka 567-0047, Japan
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O8 – Heiko Sievers
Protein – nucleic acid interactions and enzymatic activity investigated with electro-switchable biosurfaces: switchSENSE
Dynamic Biosensors GmbH, Martinsried, Germany
[/vc_column_text][/vc_column][/vc_row][vc_row row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” header_style=”” parallax_content_width=”in_grid” anchor=”” in_content_menu=”” content_menu_title=”” content_menu_icon=”” angled_section=”no” angled_section_position=”both” angled_section_direction=”from_left_to_right” text_align=”left” video=”” video_overlay=”” video_overlay_image=”” video_webm=”” video_mp4=”” video_ogv=”” video_image=”” background_image=”” background_image_as_pattern=”without_pattern” section_height=”” parallax_speed=”” background_color=”” border_color=”” row_negative_margin=”” side_padding=”” parallax_side_padding=”” padding_top=”” padding_bottom=”” color=”” hover_color=”” more_button_label=”” less_button_label=”” button_position=”” css_animation=”” transition_delay=””][vc_column width=”1/1″][vc_empty_space height=”25px” background_image=”” image_repeat=”no-repeat”][vc_separator type=”normal” position=”center” color=”#303030″ thickness=”1″ width_in_percentages=””][vc_empty_space height=”25px” image_repeat=”no-repeat”][/vc_column][/vc_row][vc_row row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” header_style=”” parallax_content_width=”in_grid” anchor=”” in_content_menu=”” content_menu_title=”” content_menu_icon=”” angled_section=”no” angled_section_position=”both” angled_section_direction=”from_left_to_right” text_align=”left” video=”” video_overlay=”” video_overlay_image=”” video_webm=”” video_mp4=”” video_ogv=”” video_image=”” background_image=”” background_image_as_pattern=”without_pattern” section_height=”” parallax_speed=”” background_color=”” border_color=”” row_negative_margin=”” side_padding=”” parallax_side_padding=”” padding_top=”” padding_bottom=”” color=”” hover_color=”” more_button_label=”” less_button_label=”” button_position=”” css_animation=”” transition_delay=”” el_id=””][vc_column width=”1/4″][vc_column_text]12:10 – 14:30[/vc_column_text][/vc_column][vc_column width=”3/4″][vc_column_text css=”.vc_custom_1465207178014{margin-bottom: 10px !important;}”]
[/vc_column_text][/vc_column][/vc_row][vc_row row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” header_style=”” parallax_content_width=”in_grid” anchor=”” in_content_menu=”” content_menu_title=”” content_menu_icon=”” angled_section=”no” angled_section_position=”both” angled_section_direction=”from_left_to_right” text_align=”left” video=”” video_overlay=”” video_overlay_image=”” video_webm=”” video_mp4=”” video_ogv=”” video_image=”” background_image=”” background_image_as_pattern=”without_pattern” section_height=”” parallax_speed=”” background_color=”” border_color=”” row_negative_margin=”” side_padding=”” parallax_side_padding=”” padding_top=”” padding_bottom=”” color=”” hover_color=”” more_button_label=”” less_button_label=”” button_position=”” css_animation=”” transition_delay=”” el_id=””][vc_column width=”1/1″][vc_empty_space height=”25px” background_image=”” image_repeat=”no-repeat”][vc_separator type=”normal” position=”center” color=”#303030″ transparency=”” thickness=”1″ width=”” width_in_percentages=”” up=”” down=””][vc_empty_space height=”25px” background_image=”” image_repeat=”no-repeat”][/vc_column][/vc_row][vc_row row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” header_style=”” parallax_content_width=”in_grid” anchor=”” in_content_menu=”” content_menu_title=”” content_menu_icon=”” angled_section=”no” angled_section_position=”both” angled_section_direction=”from_left_to_right” text_align=”left” video=”” video_overlay=”” video_overlay_image=”” video_webm=”” video_mp4=”” video_ogv=”” video_image=”” background_image=”” background_image_as_pattern=”without_pattern” section_height=”” parallax_speed=”” background_color=”” border_color=”” row_negative_margin=”” side_padding=”” parallax_side_padding=”” padding_top=”” padding_bottom=”” color=”” hover_color=”” more_button_label=”” less_button_label=”” button_position=”” css_animation=”” transition_delay=”” el_id=””][vc_column width=”1/4″][vc_column_text]14:30 – 16:10[/vc_column_text][/vc_column][vc_column width=”3/4″][vc_column_text css=”.vc_custom_1465210808590{margin-bottom: 10px !important;}”]
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O9 – Clemens Entzian, Lukas Kniep, Corinna Kuttenberger, Thomas Schubert
Studying aptamer-target interactions using MicroScale Thermophoresis
2bind GmbH, Josef Engert Straße 13, 93053 Regensburg
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O10 – Elisa Biondi1, Kwame Sefah2, Liquin Zhang2, Zunyi Yang1, Shuichi Hoshika1, Kevin M. Bradley1, Steven A. Benner1,3
Development and Application of New Aptamer Technologies for Artificially Expanded Genetic Information Systems.
1 Foundation for Applied Molecular Evolution (FfAME), Alachua – FL, USA
2 Department of Chemistry, University of Florida, Gainesville – FL, USA
3 Firebird Molecular Sciences LLC, Alachua – FL, USA
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O11- Adam A. Friedman, Rihe Liu
Highly Stable Aptamers Directly Selected from a 2′-Fully Modified RNA Library
Eshelman School of Pharmacy, Division of Chemical Biology and Medicinal Chemistry, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA.
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O12 – Philipp Holliger (SB2 lecture)
Synthetic genetics: beyond DNA and RNA.
MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK
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O13 – Ichiro Hirao
Creation of high-affinity DNA aptamers using a genetic alphabet expansion system.
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #04-01, Singapore 138669
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O14 – Curtis H. Lam, Nancy Ward1, Johnnie Engelhardt1, Montamas Suntravat2, Peter Davies2, Elda E. Sanchez2, David G. Gorenstein1
Non-SELEX Selection of X-Aptamers for Snake Venom Myotoxin
1 AM Biotechnologies, Houston, USA
2 National Natural Toxins Research Center, Texas A&M University Kingsville, Kingsville, USA
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O15 – Chenze Lu1,2,3, Arnaud Buhot1,2,3, Yoann Roupioz1,2,3, Didier Gasparutto1,2,3, Eric Peyrin4
Target induced DNA self-assembling: detection of small targets by DNA network formation
1 University Grenoble Alpes, INAC-SPrAM, F-38000 Grenoble, France
2 CEA, INAC-SPrAM, F-38000 Grenoble, France
3 CNRS, INAC-SPrAM, F-38000 Grenoble, France
4 University Grenoble Alpes, DPM UMR 5063, Grenoble, France.
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O16 – Eric Peyrin, Emmanuelle Fiore, Valérie Guieu, Sandrine Perrier, Corinne Ravelet
Fluorescence Anisotropy Spectroscopy in Aptamer-based Biosensing
Département de Pharmacochimie Moléculaire, Université Grenoble Alpes, UMR 5063 CNRS, ICMG FR 2607, Campus universitaire, Saint-Martin d’Hères, France
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O17 – Günter Mayer1,2, Valeriy Domenyuk1, Zhenyu Zhong1, Adam Stark1, Jie Wang1, Sonal Tonapi, Heather O’Neill1, Nianqing Xiao1, Mark R. Miglarese1, Michael Famulok1,2,3, and David B. Spetzler1
Adaptive Dynamic Artificial Poly-ligand Targeting (ADAPT): a highly multiplexed aptamer- based biomarker discovery platform
1Caris Life Sciences, Phoenix, AZ
2LIMES Program Unit Chemical Biology & Medicinal Chemistry, University of Bonn, Germany
3Chemical Biology Max-Planck-Fellowship Group, Center of Advanced European Studies and Research, Bonn, Germany.
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O18 – 1 Flavia Zimbres, 2 Arthur A. Nery, 1*Carsten Wrenger, 2Henning Ulrich
Aptamer Ligands for Plasmodium falciparum-infected erythrocytes
1Department of Parasitology, Institute of Biological Sciences (ICB), University of São Paulo
2Department of Biochemistry, Institute of Chemistry, University of São Paulo, Brazil.
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O19 – Miriam Jauset-Rubioa, Markéta Svobodováa, Teresa Mairala, Mohammad S. El-Shahawic, Abdulaziz S. Bashammakhc, Abdulrahman O. Alyoubic and Ciara K. O ́Sullivana,c
Ultrasensitive β-conglutin detection via recombinase polymerase amplification-lateral flow competitive assay
a Nanobiotechnology and Bioanalysis group, Department of Chemical Engineering, Universitat Rovira I Virgili, 43007 Tarragona, Spai
b Department of Chemistry, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah 21589, Kingdom of Saudi Arabia
c Institució Catalana de Recerca I Estudis Avancats, Passeig Lluís Companys 23, 08010 Barcelona, Spain
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O20 – Larry Gold (SIRIC BRIO lecture)
SOMAscan Protein Profiling and Clinical and Health Monitoring Utility.
SomaLogic, Inc. – 2945 Wilderness Place – Boulder, CO 80301, USA
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O21 – Samie R. Jaffrey (TRAIL lecture)
Imaging RNA and RNA biology using RNA mimics of green fluorescent protein
Department of Pharmacology, Weill Cornell Medical College, Cornell University New York, NY 10065, United States
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O22 – Nam Nguyen Quang1,2,3, Clément Bouvier1,2,3, Benoit Lelandais1,2,3 and Frédéric Ducongé1,2,3.
Improvement of aptamers using PATTERNITY-seq (high-throughput patterns paternity analysis).
1The Neurodegenerative Diseases Laboratory (LMN), CEA-CNRS UMR 9199, Université Paris- Saclay, Fontenay aux roses, France
2 Molecular Imaging Research Center (MIRCen), Institute of Biomedical Imaging (I2BM)
3CEA SCIENCES, Fontenay aux roses, France.
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O23 – Anna Zamay1, Mariia Komarova1, Andrey Narodov1,2, Galina Zamay1, Igor Grinev2, Tatiana Ivanchenko1, Dmitry Veprincev1, Olga Kolovskaya1, Yury Glazyrin1, Evgeniy Erakhtin2, Marina Petrova1, Ivan Artyukhov1, Ana Gargaun3, Maxim V. Berezovski3, Tatiana Zamay1
Tumor Specific Aptamers Navigate Glioblastoma Neurosurgery
1Krasnoyarsk State Medical University named after prof. V.F. Voyno-Yasenetskii, Krasnoyarsk , Russia
2Krasnoyarsk Inter-District Ambulance Hospital named after N.S. Karpovich, Krasnoyarsk, Russia;
3University of Ottawa, Ontario, Canada
[/vc_column_text][/vc_column][/vc_row][vc_row row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” header_style=”” parallax_content_width=”in_grid” anchor=”” in_content_menu=”” content_menu_title=”” content_menu_icon=”” angled_section=”no” angled_section_position=”both” angled_section_direction=”from_left_to_right” text_align=”left” video=”” video_overlay=”” video_overlay_image=”” video_webm=”” video_mp4=”” video_ogv=”” video_image=”” background_image=”” background_image_as_pattern=”without_pattern” section_height=”” parallax_speed=”” background_color=”” border_color=”” row_negative_margin=”” side_padding=”” parallax_side_padding=”” padding_top=”” padding_bottom=”” color=”” hover_color=”” more_button_label=”” less_button_label=”” button_position=”” css_animation=”” transition_delay=”” el_id=””][vc_column width=”1/1″][vc_empty_space height=”25px” background_image=”” image_repeat=”no-repeat”][vc_separator type=”normal” position=”center” color=”#303030″ transparency=”” thickness=”1″ width=”” width_in_percentages=”” up=”” down=””][vc_empty_space height=”25px” background_image=”” image_repeat=”no-repeat”][/vc_column][/vc_row][vc_row row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” header_style=”” parallax_content_width=”in_grid” anchor=”” in_content_menu=”” content_menu_title=”” content_menu_icon=”” angled_section=”no” angled_section_position=”both” angled_section_direction=”from_left_to_right” text_align=”left” video=”” video_overlay=”” video_overlay_image=”” video_webm=”” video_mp4=”” video_ogv=”” video_image=”” background_image=”” background_image_as_pattern=”without_pattern” section_height=”” parallax_speed=”” background_color=”” border_color=”” row_negative_margin=”” side_padding=”” parallax_side_padding=”” padding_top=”” padding_bottom=”” color=”” hover_color=”” more_button_label=”” less_button_label=”” button_position=”” css_animation=”” transition_delay=”” el_id=””][vc_column width=”1/4″][vc_column_text]12:10 – 14:30[/vc_column_text][/vc_column][vc_column width=”3/4″][vc_column_text css=”.vc_custom_1465207148694{margin-bottom: 10px !important;}”]
[/vc_column_text][/vc_column][/vc_row][vc_row row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” header_style=”” parallax_content_width=”in_grid” anchor=”” in_content_menu=”” content_menu_title=”” content_menu_icon=”” angled_section=”no” angled_section_position=”both” angled_section_direction=”from_left_to_right” text_align=”left” video=”” video_overlay=”” video_overlay_image=”” video_webm=”” video_mp4=”” video_ogv=”” video_image=”” background_image=”” background_image_as_pattern=”without_pattern” section_height=”” parallax_speed=”” background_color=”” border_color=”” row_negative_margin=”” side_padding=”” parallax_side_padding=”” padding_top=”” padding_bottom=”” color=”” hover_color=”” more_button_label=”” less_button_label=”” button_position=”” css_animation=”” transition_delay=”” el_id=””][vc_column width=”1/1″][vc_empty_space height=”25px” background_image=”” image_repeat=”no-repeat”][vc_separator type=”normal” position=”center” color=”#303030″ transparency=”” thickness=”1″ width=”” width_in_percentages=”” up=”” down=””][vc_empty_space height=”25px” background_image=”” image_repeat=”no-repeat”][/vc_column][/vc_row][vc_row row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” header_style=”” parallax_content_width=”in_grid” anchor=”” in_content_menu=”” content_menu_title=”” content_menu_icon=”” angled_section=”no” angled_section_position=”both” angled_section_direction=”from_left_to_right” text_align=”left” video=”” video_overlay=”” video_overlay_image=”” video_webm=”” video_mp4=”” video_ogv=”” video_image=”” background_image=”” background_image_as_pattern=”without_pattern” section_height=”” parallax_speed=”” background_color=”” border_color=”” row_negative_margin=”” side_padding=”” parallax_side_padding=”” padding_top=”” padding_bottom=”” color=”” hover_color=”” more_button_label=”” less_button_label=”” button_position=”” css_animation=”” transition_delay=”” el_id=””][vc_column width=”1/4″][vc_column_text]14:30 – 16:10[/vc_column_text][/vc_column][vc_column width=”3/4″][vc_column_text css=”.vc_custom_1465210890805{margin-bottom: 10px !important;}”]
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O24 – Valeriy Domenyuk1, Zhenyu Zhong1, Jie Wang1, Adam Stark1, Xixi Wei1, Patrick Kennedy1, Brandon Toussaint1, Radhika Santhanam1, Symon Levenberg1, Nianqing Xiao1, Mark R. Miglarese1, David Halbert1, George Poste2, Michael Famulok3,4, Günter Mayer4 and David B. Spetzler1.
Plasma Exosome Profiling of Cancer Patients by a Next Generation Systems Biology Approach Using Large Aptamer Libraries
1Caris Life Sciences, Phoenix, AZ
2Complex Adaptive Systems Initiative, Arizona State University, Scottsdale, AZ 85257, USA
3Chemical Biology Max-Planck-Fellowship Group, Center of Advanced European Studies and Research, Bonn, Germany;
4LIMES Program Unit Chemical Biology & Medicinal Chemistry, University of Bonn, Germany
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O25 – Darija Muharemagic1, Anna S. Zamay1,2, Shahrokh M. Ghobadloo1, John C Bell3, Maxim V. Berezovski1
Aptamer-facilitated Protection of Oncolytic Virus from Neutralizing Antibodies
1Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada
2Krasnoyarsk State Medical University, Krasnoyarsk, Russia
3Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada;
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O26 – Jean Gariépy1,2,4, Ismat Khatri3, Kathak Vacchani5, Cari Whyne 4,5, Diane Nam5, Marzena Cydzik4, Reginald Gorczynski3, and Aaron Prodeus1,4
A DNA aptamer that acts as a CD200R1 immune checkpoint agonist in vitro and in vivo and recognizes both human and mouse CD200R1
1 Department of Medical Biophysics, University of Toronto, Toronto, Canada
2 Department of Pharmaceutical Sciences, Department of Medical Biophysics, University of Toronto, Toronto, Canada
3 Department of Immunology, University of Toronto
4 Physical Sciences, Sunnybrook Research Institute, Toronto, Canada
5 Holland Musculoskeletal Research Program, Sunnybrook Research Institute, Toronto, Canada
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O27 – H. Tom Soh
Continuous, Real-Time Detection of Biomolecules in Live Animals
Department of Electrical Engineering and Radiology, Stanford University, Stanford, CA 94305, USA
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O28 – William H Thiel1 , Carla L Esposito2 , David D Dickey1 , Justin P Dassie1, Matthew E Long3, Joshu Adam1 , Jennifer Streeter1, Brandon Schickling1 , Maysam Takapoo1, Katie S Flenker1, Julia Klesney-Tait1, Vittorio de Franciscis2, Francis J Miller Jr1,4 , Paloma H Giangrande1
1 Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
2Istituto di Endocrinologia ed Oncologia Sperimentale, CNR, Naples, Italy
3Department of Microbiology, University of Washington, Seattle, WA 98109, USA
4 The Veterans Affair Medical Center, Iowa City, IA, USA 52242, USA
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O30 – Bruce Sullenger, Ruwan Gunaratne, James Frederiksen, Kady-Ann Steen-Burrell, Bethany Gray
Therapeutic and Diagnostic Applications of Rapidly Reversible Aptamers
Duke Translational Research Institute, Department of Surgery, Duke University, Durham, North Carolina, USA
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O31 – Brett Schrand1, Bhavana Verma1, Agata Levay1, Shradha Patel1, Iris Castro1, Oliver Umland2, Ana Paula Benaduce3, Randall Brenneman1, Eli Gilboa1, Adrian Ishkanian3.
Vegf-targeted 4-1BB costimulation enhances radiation-induced immune control of tumor growth
1Department of Microbiology and Immunology, Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, University of Miami, MSOM, Miami, Florida
2Diabetes Research Institute, University of Miami, MSOM, Miami, Florida
3Department of Radiation Oncology, University of Miami, MSOM, Miami, Florida.
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O32 – Carla Lucia Esposito, Silvia Nuzzo, Anna Rienzo, Silvia Catuogno and Vittorio de Franciscis
Aptamer carriers for Cancer Stem Cell-Targeted Delivery of Therapeutic miRNAs
Institute of Experimental Endocrinology and Oncology – CNR, Naples, Italy
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